Article ID Journal Published Year Pages File Type
10835624 Peptides 2012 12 Pages PDF
Abstract
► DNA plasmids containing coding sequences of CPP, HA2, and RFP were constructed. ► Endocytosis is the major route for cellular uptake of CPP-HA2-tagged RFPs. ► HA2 tag of the CPP-HA2 fusion protein improved cytosolic uptake in human A549 cells. ► CPP-HA2-tagged RFP fusion proteins did not display cytotoxicity. ► The CPP-HA2 tag could be an efficient and safe carrier of bioactive molecules.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Protein transduction in human cells is enhanced by cell-penetrating peptides fused with an endosomolytic HA2 sequence
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