Article ID Journal Published Year Pages File Type
10835632 Peptides 2012 7 Pages PDF
Abstract
► We studied the neurohypophyseal hormones on seizures in zebrafish. ► We evaluated the epileptic behavior induced by pentylenetetrazole. ► Oxytocin (OT), vasopressin, isotocin and vasotocin reduced epileptic behavior. ► OT and vasopressin V1a receptor antagonists selectively antagonized the protection. ► These hormones are anticonvulsant agents through a receptor-mediated mechanism.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Neurohypophyseal hormones protect against pentylenetetrazole-induced seizures in zebrafish: Role of oxytocin-like and V1a-like receptor
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