| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835666 | Peptides | 2012 | 7 Pages |
Abstract
⺠Prolactin was studied in mice with genetic manipulation of the melanocortin system. ⺠Mice with MSH overexpression (Tg-MSH) and AgRP deletion (AgRP KO) were utilized. ⺠Baseline and stress-induced blood prolactin levels were reduced in Tg-MSH vs. WT. ⺠Blood and pituitary prolactin levels were reduced in AgRP KO vs. WT. ⺠Differences in hypothalamic tyrosine hydroxylase and dopamine were not detected.
Keywords
α-MSHMC-Rβ-EPTIDAACTHDHBAMBHDOPACDOPAD2RAgRPPOMC3,4-dihydroxybenzylamine3,4-dihydroxyphenylalanine3,4-dihydroxyphenylacetic acidPCAβ-endorphinadrenocorticotropinPerchloric acidCMVcytomegalovirusmelanocortinα-melanocyte-stimulating hormoneMediobasal hypothalamusAgouti-related proteinProlactinproopiomelanocortinmelanocortin receptor
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Authors
Roxanne Dutia, Andrea J. Kim, Eugene Mosharov, Eriika Savontaus, Streamson C. Jr., Sharon L. Wardlaw,