Surface masking shapes the traffic of the neuropeptide Y Y2 receptor

Article ID	Journal	Published Year	Pages	File Type
10835671	Peptides	2012	9 Pages	PDF

Abstract

âº Surface Y2 receptor in CHO cells are largely masked to the agonist peptides. âº This is due to adhesion of extracelular domains, especially the N-terminal. âº Removal of masking by cell dispersion strongly increases receptor traffic.

Keywords

GTPγS pPYY MTSET BIIE0246 HPP GPCR N-ethylmaleimide PDB PAO 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate G-protein-coupled receptor guanosine 5′-O-(3-thiotriphosphate)Phenylarsine oxide CHO cells NEM human pancreatic polypeptide Protein Data Bank CHAPS