Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10835677 | Peptides | 2012 | 12 Pages |
Abstract
⺠Netupitant behaves in vitro as a highly potent and selective NK1 receptor antagonist. ⺠In bioassay washout experiments, Netupitant displayed persistent (up to 5 h) antagonist effects. ⺠Netupitant antagonizes nociceptive responses to intrathecal substance P in mice. ⺠Netupitant prevents foot tapping induced by a NK1 agonist in gerbils showing long lasting effects. ⺠Netupitant is as a brain penetrant, orally active, potent and selective NK1 antagonist.
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Authors
Anna Rizzi, Barbara Campi, Valeria Camarda, Stefano Molinari, Sergio Cantoreggi, Domenico Regoli, Claudio Pietra, Girolamo Calo',