| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835688 | Peptides | 2012 | 6 Pages |
Abstract
⺠Supraspinal apelin-13 induced antinociceptive effect in the visceral pain model. ⺠I.t. (not i.p.) injected apelin-13 produced antinociception in the writhing test. ⺠The antinociception of i.c.v. apelin-13 was mediated by APJ and μ-opioid receptor. ⺠Apelin-13 could significantly potentiate the antinociceptive effect of morphine. ⺠This potentiated analgesic response was fully blocked by naloxone.
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Authors
Shuang-Yu Lv, Yao-Jun Qin, Ning-Bo Wang, Yan-Jie Yang, Qiang Chen,