Inhibitory role of kinins on microglial nitric oxide and tumor necrosis factor-α production

► Three kinin agonists attenuate LPS-induced NO and TNF-α production in BV2 cells. ► Bradykinin reduced basal NO and TNF-α production in BV2 cells. ► Anti-inflammatory effects of bradykinin were confirmed in primary microglia. ► Three kinin agonists reduce LPS-induced iNOS and TNF-α protein and mRNA levels in BV2 cells. ► Bradykinin abolishes LPS-induced NF-κB pathway activation in BV2 cells.