Article ID Journal Published Year Pages File Type
10835701 Peptides 2012 6 Pages PDF
Abstract
► Serum ACE processes Ang-(1-12) to Ang II through the generation of Ang I. ► Serum renin does not metabolize Ang-(1-12) to shorter angiotensin peptides. ► Rat, human and mouse neprilysin process Ang-(1-12) to Ang-(1-7) and Ang-(1-4). ► Kinetic modeling does not favor Ang-(1-12) as the immediate precursor to Ang I.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Divergent pathways for the angiotensin-(1-12) metabolism in the rat circulation and kidney
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