Lysine substitutions convert a bacterial-agglutinating peptide into a bactericidal peptide that retains anti-lipopolysaccharide activity and low hemolytic activity

Article ID	Journal	Published Year	Pages	File Type
10835707	Peptides	2012	8 Pages	PDF

Abstract

âº Lysine substitution converts an agglutinating peptide to a bactericidal peptide. âº The peptide retains activity in saliva and in vivo. âº The peptide exhibits anti-lipopolysaccharide activity in vitro and in vivo. âº A serine hydroxyl is necessary for anti-LPS activity but not bactericidal activity. âº The peptide has low hemolytic activity.

Keywords

CFU Parotid secretory protein PLUNC BPI PSP MIC LPS PBS Agglutination Minimum inhibitory concentration Bactericidal lipopolysaccharide Phosphate-buffered saline Hemolysis colony forming units Bactericidal/permeability-increasing protein optical density