| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835740 | Peptides | 2012 | 9 Pages |
Abstract
⺠Cyclic-7mer peptides displaying brain tropism were identified by in vivo phage display. ⺠349 unique peptides were associated with gray matter (microvasculature and parenchyma). ⺠Amino acid distribution suggested a theoretical ideal peptide sequence PP(S/P)SSST. ⺠Phage displaying SYTSSTM were recovered at highest frequency from brain gray matter. ⺠SYTSSTM phage showed a 5-fold greater brain accumulation compared to control phage.
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Authors
Mathew W. Smith, Ghaith Al-Jayyoussi, Mark Gumbleton,