| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835759 | Peptides | 2011 | 11 Pages |
Abstract
⺠Co-administration of AM and SB431542 enhanced differentiation of LYVE-1/stabilin-2-positive endothelial cells in EBs-culture system. ⺠These cells showed robust endocytosis and upregulated expression of LSEC-specific markers and possess fenestrae-like structure. ⺠In RAMP2-null liver, LYVE-1 was downregulated in LSEC, and the sinusoidal structure was disrupted. ⺠Our findings highlight the importance of AM-RAMP2 signaling for development of LSEC.
Keywords
Lymphatic vessel endothelial hyaluronan receptor-1VEGFRLYVE-1LECsESCsAdrenomedullin (AM)VEGF-AAc-LDLCRLREBsMrc1GPCRTGFβLSECadrenomedullinTransforming growth factor βembryoid bodiesrampLiver sinusoidal endothelial cellsLymphatic endothelial cellsEmbryonic stem cellsVascular endothelial growth factor Aacetylated low-density lipoproteinStabilin-2Receptor activity-modifying proteinvascular endothelial growth factor receptorcalcitonin receptor-like receptorG protein-coupled receptor
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Authors
Takuma Arai, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Nobuyoshi Iinuma, Yasuhiro Iesato, Teruhide Koyama, Takahiro Yoshizawa, Ryuichi Uetake, Akihiro Yamauchi, Lei Yang, Hisaka Kawate, Shinichiro Ogawa, Akira Kobayashi, Shinichi Miyagawa,