| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835762 | Peptides | 2011 | 11 Pages |
Abstract
⺠Growth hormone secretagogue receptor1a (GHS-R1a) was identified in guinea-pig brain cDNA and compared with that of other animals. ⺠Guinea-pig GHS-R1a expressed in HEK 293 cells responded to ghrelin, GHRP-6 and hexarelin in a concentration-dependent manner. ⺠GHS-R1a mRNA expression was high in the pituitary and hypothalamus, but very low in the gastrointestinal tract. ⺠Ghrelin was ineffective in producing responses in the stomach and colon but caused slight contraction in the small intestine. ⺠Functional roles of ghrelin and peripheral GHS-R1a for regulation of gastrointestinal motility are weak in guinea-pigs compared with other animal species.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Takio Kitazawa, Tatsuro Nakamura, Atsuki Saeki, Hiroki Teraoka, Takeo Hiraga, Hiroyuki Kaiya,