| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835764 | Peptides | 2011 | 9 Pages |
Abstract
⺠I.c.v. administration of neuronostatin produced a dose- and time-related antinociceptive effect in the tail immersion assay in mice. ⺠Neuronostatin produces its full analgesic effect by activating μ-and κ-opioid receptors. ⺠The analgesic effects of neuronostatin are dependent upon the central melanocortin system ⺠C-terminal amidation modification of neuronostatin is essential to exert its antinociceptive effect. ⺠Neuronostatin (6 nmol, i.c.v.) increased c-Fos protein expression in the periaqueductal gray (PAG) and the nucleus raphe magnus (NRM).
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Authors
Ai-min Yang, Wan-wen Ge, Song-song Lu, Shao-bin Yang, Shu-fang Su, Ze-yun Mi, Qiang Chen,