| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835811 | Peptides | 2012 | 9 Pages |
Abstract
⺠The effects of the Haemaphysalis longicornis longicin P4 peptide on the morphology state of Toxoplasma gondii tachyzoites were examined. ⺠Tachyzoites incubated with longicin P4 had been induced the pathological changes of cell morphology. ⺠The number of tachyzoites proliferated in mouse macrophage cell line (J774A.1) was significantly decreased by incubation with longicin P4. ⺠These findings suggested that longicin P4 conceivably impaired parasite membranes, leading to the destruction of tachyzoites in J774A.1 cells. ⺠Longicin P4 hold great promise for studying as an anti-toxoplasmosis molecule.
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Authors
Tetsuya Tanaka, Hiroki Maeda, Tomohide Matsuo, Damdinsuren Boldbattar, Rika Umemiya-Shirafuji, Aiko Kume, Hiroshi Suzuki, Xuenan Xuan, Naotoshi Tsuji, Kozo Fujisaki,