Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice

► Comprehensive study investigating actions of GLP-1(9-36)amide and GIP(3-42) on locomotor activity, memory and learning and hippocampal long-term potentiation in high-fat fed mice. ► Truncated incretin metabolites did not alter general locomotor activity or learning ability of high-fat fed mice during an object recognition test. ► High-fat mice demonstrated impairment in hippocampal synaptic plasticity which was not affected by incretin metabolites. ► Changes in circulating concentrations of incretin metabolites are unlikely to have a negative impact on cognitive function.