CCK-B receptor gene and response to cholecystokinin-tetrapeptide in healthy volunteers

► CCKBR (CT) polymorphism alleles 26 and 27 are associated with panic disorder (PD). ► We determined whether these alleles modulated panicogenic sensitivity to CCK-4 in healthy volunteers. ► We could not demonstrate that these PD risk alleles enhanced sensitivity to CCK-4. ► However, carriers of the alleles were more anxiety sensitive and introverted and they tended to experience higher pre-challenge levels of anxiety.