| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835825 | Peptides | 2012 | 7 Pages |
Abstract
⺠This is the first study where the fate of proTRH biosynthesis and processing is analyzed in PC1KO and PC2KO mice. ⺠The current in vivo study confirms our initial in vitro and ex vivo findings demonstrating that PC1 plays a primary role in proTRH processing. ⺠PC1 is necessary to maintain normal levels of the biologically active thyroid hormone T3. ⺠PC2 is required for the conversion of the proTRH-derived peptide pFE22 to pFQ7, and pSE14, which may function to regulate prolactin.
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Authors
Nicole E. Cyr, Ronald C. Stuart, Xiaorong Zhu, Donald F. Steiner, Eduardo. A. Nillni,