| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835831 | Peptides | 2012 | 8 Pages |
Abstract
⺠Peptide therapy attenuates hypoxia-induced pulmonary artery hypertension and vascular remodeling. ⺠The effect was found to be mediated by increased NO-release and inhibition of cGMP-specific PDE-5. ⺠Dual action of the peptide that enhance NO release and diminished PDE-5 activity resulted in sustained elevation of cGMP. ⺠This novel peptide has therapeutic potential for NO/cGMP-dependent modulation of hemodynamic and structural changes in the pulmonary circulation.
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Authors
Hanbo Hu, Sergey Zharikov, Jawaharlal M. Patel,