| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835848 | Peptides | 2011 | 8 Pages |
Abstract
⺠Generation and characterization of ELKO and ALKO mice for the first time. ⺠Illustrating that membrane-bound mutant receptors without signaling functions can mediate leptin transport across the BBB. ⺠Leptin signaling may hinder its own transport across endothelial barrier. ⺠Astrocytic leptin receptors do not play a crucial role in basal level leptin transport. ⺠Implications for obesity, metabolic syndrome, and neuroinflammation.
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Authors
Hung Hsuchou, Abba J. Kastin, Hong Tu, Emily N. Markadakis, Kirsten P. Stone, Yuping Wang, Steven B. Heymsfield, Streamson S. Jr., Silvana Obici, I. Jack Magrisso, Weihong Pan,