Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10835861 | Peptides | 2011 | 8 Pages |
Abstract
⺠In the presence of NaCl, CaCl2 or human serum albumin at physiological concentrations, inhibitory effects of physiological conditions on antimicrobial activity of enantiomeric peptides have been investigated. ⺠The electrostatic interaction between peptides and biomembrane was inhibited in the presence of salts. ⺠Salts especially CaCl2 weakened the ability of peptides to permeabilize the outer membrane of Gram-negative bacteria. ⺠Peptide showed different binding association abilities to HSA at different molar ratios, which is irrelevant to the peptide chirality and caused the reduction of peptide antimicrobial activity. ⺠d-peptide showed better performance than its l-enantiomer in all tested conditions owing to its resistance against proteolysis, hence, may be a promising candidate as therapeutic in clinical practices.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Jinfeng Huang, Dianming Hao, Yu Chen, Yimin Xu, Juanjuan Tan, Yibing Huang, Fan Li, Yuxin Chen,