| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835864 | Peptides | 2011 | 9 Pages |
Abstract
⺠We describe the κ-KTx2.5 and show it is a blocker of hKv1.1, and hKv1.4 channels. ⺠CD spectra showed a predominance of α-helices at different temperatures in water and water/TFE. ⺠κ-KTx2.5 had no activity on other ion channels, on bacterial growth and on smooth muscle tissue. ⺠A structural model of the kappa-KTx2.5-Kv1.2 complex is presented.
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Authors
Thalita Soares Camargos, Rita Restano-Cassulini, Lourival Domingos Possani, Steve Peigneur, Jan Tytgat, Carlos Alberto Schwartz, Erica Maria C Alves, Sonia Maria de Freitas, Elisabeth Ferroni Schwartz,