| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835923 | Peptides | 2011 | 10 Pages |
Abstract
⺠Ghrelin has direct effects on pancreatic islet function. ⺠Available data indicate the potential of ghrelin blockade as a means to prevent its diabetogenic effects. ⺠Direct antagonism of the receptor does not always have the desired effects, however, since it can cause increased body weight gain. ⺠Pharmacological suppression of the ghrelin/des-acyl ghrelin ratio by treatment with des-acyl ghrelin may also be a viable alternative approach which appears to improve insulin sensitivity. ⺠A promising new approach appears to be the blockade of GOAT activity.
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Authors
P.J.D. Delhanty, A.J. van der Lely,