| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835940 | Peptides | 2009 | 7 Pages |
Abstract
⺠We first found the direct anti-E. coli activity of histone H3. ⺠The modes of antimicrobial action of Arg-rich (H3 and H4) and Lys-rich (H2B) histones are different. ⺠We found that the Arg-rich histones disrupt the cell membrane of ompT-expressing E. coli strains by forming blebs. ⺠The Lys-rich histone translocates the membrane without causing membrane lysis. ⺠Bacterial OmpT is involved in these modes of action through digestion of histones.
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Authors
Chihiro Tagai, Shuu Morita, Takayuki Shiraishi, Kazuyuki Miyaji, Shawichi Iwamuro,