Article ID Journal Published Year Pages File Type
10835952 Peptides 2011 6 Pages PDF
Abstract
► The role of gastrin-releasing peptide released from primary afferent on itch was demonstrated. ► Gastrin-releasing peptide elicits scratching, an itch-related response, in mice though BB2 bombesin receptor. ► Gastrin-releasing peptide-induced scratching is inhibited by H1 histamine receptor antagonists and PAR2 proteinase-activated receptor antagonist. ► Gastrin-releasing peptide-induced scratching may be elicited through the activation of mast cells.
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