| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835955 | Peptides | 2011 | 6 Pages |
Abstract
⺠Angiotensin II (Ang II)-induced constriction was evaluated in mesenteric venules and portal vein of hypertensive rats (SHR). ⺠In SHR portal vein, Ang II-constriction was reduced when compared to normotensive Wistar rats. ⺠AT2 receptor protein expression and mRNA levels were reduced in portal vein from SHR. ⺠In SHR, Ang II venoconstriction was mediated by AT1 receptors and was counterbalanced by kinin B2 receptor and COX metabolites. ⺠Different cellular and molecular mechanisms are involved in the venous control of normotensive and hypertensive rats.
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Authors
Rodrigo Azevedo Loiola, Liliam Fernandes, Rosângela Eichler, Rita de Cássia Tostes Passaglia, Zuleica Bruno Fortes, Maria Helena Catelli de Carvalho,