| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835961 | Peptides | 2011 | 10 Pages |
Abstract
⺠All the elements of the RAS are present in the vasculature, indicating that the vascular system may act independently from the systemic RAS to generate Ang II. ⺠Vascular renin probably derives primarily from circulating kidney-derived renin. ⺠New components of the RAS have been identified in the vascular wall, including (P)RR, Ang-(1-7), Ang III, Ang IV, ACE2 and ProAng-12. ⺠Ang II generated from immune and inflammatory cells contributes to Ang II levels in the vascular wall. ⺠Activation of the RAS in perivascular adipose tissue contributes to the vascular RAS and influences vascular function. ⺠Functionally the vascular RAS may amplify vascular effects of the circulating RAS.
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Authors
Aurelie Nguyen Dinh Cat, Rhian M. Touyz,