Article ID Journal Published Year Pages File Type
10835965 Peptides 2011 8 Pages PDF
Abstract

- Leptin and a leptin receptor agonist peptide constitutively activate the NF-κB pathway in peripheral blood mononuclear cells, and the leptin receptor antagonist peptide Allo-aca reverses the process.
- In a mouse serum transfer rheumatoid arthritis model, Allo-aca added subcutaneously partially inhibits the proinflammatory effects of leptin.
- In a rat adjuvant-induced rheumatoid arthritis, Allo-aca reverses all inflammatory symptoms in early stages, but is only partially effective in a more advanced disease.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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