Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10835965 | Peptides | 2011 | 8 Pages |
Abstract
- Leptin and a leptin receptor agonist peptide constitutively activate the NF-κB pathway in peripheral blood mononuclear cells, and the leptin receptor antagonist peptide Allo-aca reverses the process.
- In a mouse serum transfer rheumatoid arthritis model, Allo-aca added subcutaneously partially inhibits the proinflammatory effects of leptin.
- In a rat adjuvant-induced rheumatoid arthritis, Allo-aca reverses all inflammatory symptoms in early stages, but is only partially effective in a more advanced disease.
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Authors
Laszlo Jr., Wen-Hai Shao, Anne S. Vanniasinghe, Michael A. Amon, Marianna Csilla Holub, Ilona Kovalszky, John D. Wade, Michelle Doll, Philip L. Cohen, Nicholas Manolios, Eva Surmacz,