Article ID Journal Published Year Pages File Type
10835966 Peptides 2011 6 Pages PDF
Abstract
► Peripheral leptin was reported to attenuate estrogen deficiency-induced bone loss. ► Hypothalamic administration of leptin was reported to be antiosteogenic. ► We evaluated bone in ovx rats with increased hypothalamic leptin gene expression. ► Ovx resulted in severe osteopenia. ► Increasing hypothalamic leptin gene expression had no additional effect on bone.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats
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