PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells

► PAC1hop, null and hip confer cAMP generation upon PACAP treatment in NG108-15 cells. ► PAC1hop and null confer elevation of [Ca2+]i, PAC1hop more efficaciously. ► Gene induction proceeds through PAC1hop-specific combinatorial or cAMP signaling. ► Gene induction through cAMP is mediated by PKA-dependent or -independent signaling.