Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10836045 | Peptides | 2005 | 5 Pages |
Abstract
To examine the relationship between glutamate receptors and the action of NC-1900 on a step-through passive avoidance (PA) task in mice, MK-801, an NMDA receptor blocker, and (S)-4-carboxyphenylglycine (4CPG), a group I metabotropic receptor antagonist, were administered intraventricularly (i.c.v.) singly or as co-injections. The i.c.v. injection of MK-801 (0.8 μg) or 4CPG (2 μg) decreased the latency on the PA task. NC-1900 (1 ng/kg, subcutaneously (s.c.)) alone prolonged the latency on the retention trial in the PA task. MK-801 (0.2 and 0.8 μg) or 4CPG (0.5 and 2 μg) significantly inhibited the action of NC-1900, while the s.c. injection of NC-1900 did not affect latency in mice that received i.c.v. co-injection of MK-801 and 4CPG at any of the doses tested. These results suggest that glutamate receptors participate in the action of NC-1900 on learning and memory in PA task performance.
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Authors
Tomoaki Sato, Takayuki Ishida, Koh-ichi Tanaka, Nafees Chowdhurry, Masahiro Irifune, Kenji Hirate, Tamotsu Mimura, Takashige Nishikawa,