Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10836181 | Peptides | 2005 | 8 Pages |
Abstract
We investigated the effects of peripheral injection of sauvagine, a CRF2 > CRF1 receptor (corticotropin-releasing factor) agonist compared with CRF, on two sets of tonic colorectal distension (CRDs 30, 40, 50 mmHg, 3-min on/off)-induced visceromotor response (VMR) measured as area under the curve (AUC) of abdominal muscle contraction in conscious female rats. Sauvagine (10 or 20 μg/kg, s.c.) abolished the 226.7 ± 64.3% and 90.4 ± 38.1% increase in AUC to the 2nd CRD compared with the 1st CRD (performed 30 min before) in female Fisher and Sprague-Dawley (SD) rats, respectively. CRF had no effect while the CRF1 antagonist, antalarmin (20 mg/kg, s.c.), alone or with sauvagine, blocked the enhanced response to the 2nd CRD, performed 60 min after the 1st CRD, and reduced further the AUC by 33.5 ± 23.3% and 63.5 ± 7.2%, respectively in Fisher rats. These data suggest that peripheral CRF2 receptor activation exerts antinociceptive effects on CRD-induced visceral pain, whereas CRF1 contributes to visceral sensitization.
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Authors
Mulugeta Million, Céline Maillot, David A. Adelson, Tsukasa Nozu, Ariane Gauthier, Jean Rivier, George P. Chrousos, Alfred Bayati, Hillevi Mattsson, Yvette Taché,