Human sorbin is generated via splicing of an alternative transcript from the ArgBP2 gene locus

We demonstrate that the human sorbin polypeptide is generated via splicing of an alternative transcript from the ArgBP2 gene locus. Previous studies have demonstrated that the central 139 amino acid region of the porcine sorbin polypeptide exhibits 95% homology to part of the human ArgBP2 protein. Yet neither the sorbin N- nor C-terminus has been identified in ArgBP2 or any other protein to date. Using computational analysis, we locate the sorbin N- and C-termini in the human ArgBP2 gene locus, and demonstrate that they are spliced to the 5′ and 3′ ends of the 95% homologous region. In addition, several sequence anomalies were identified in the putative human sorbin cDNA (AF396457). Thus, a revised human sorbin nucleotide sequence is proposed.