The mimetics of antiadhesive peptides as the inhibitors of Mycibacterium kansasii phagocytosis

The α-guanidino acids derived of 15 proteinaceous amino acids, ω-guanidino acids with gradually increased hydrocarbon chains, and amidinated dipeptides, were tested as the mimetics of antiadhesive peptides in Mycobacteria phagocytosis inhibition. The crystal structure of ω-guanidino acids used was determined by X-ray structural analysis. It follows from our experiments that the proper distance between guanidine and carboxyl groups of effector molecules is of decisive importance for their inhibitory activity.