| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10836964 | Peptides | 2005 | 4 Pages |
Abstract
[Ala6]lGnRH-III and [Ala7]lGnRH-III have neither receptor binding nor antiproliferative activity. Replacement of His5 with Ala resulted in an analog that binds to the receptor but does not have antiproliferative activity. The results are in agreement with previous reports that modifications of Lys at position 8 are well tolerated.
Keywords
TRTGnRHNH4OACHBTUtert-butyloxycarbonyltBuBOCFMOCHOBtD-PBSFCStert-butylRP-HPLCTFAEGTADMEMEDTMgCl2ACNDTTESI-MS1-hydroxybenzotriazole1,2-Ethanedithiol9-fluorenylmethoxycarbonylDulbecco's modified Eagle MediumAmmonium acetateAcetonitrileTrifluoroacetic acidTris–HCldithiothreitolcancer growthfetal calf serumDulbecco's phosphate buffered salineGonadotropin-releasing hormonereversed-phase high performance liquid chromatographyMagnesium chlorideReceptor binding
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Authors
Krisztina Herédi-Szabó, Jeremiah Lubke, Geza Toth, Richard F. Murphy, Sándor Lovas,