Article ID Journal Published Year Pages File Type
10837813 Pharmacology Biochemistry and Behavior 2012 8 Pages PDF
Abstract
► Ursolic acid (UA) is a triterpenoid compound isolated from Rosmarinus officinalis. ► UA reduces the the immobility time in the tail suspension test (TST) and forced swimming test. ► UA does not exert psychostimulant effect in the open-field test. ► The effect of UA is mediated by an activation of dopamine D1 and D2 receptors. ► UA administration potentiates the effect of bupropion in the TST.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system
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