Article ID Journal Published Year Pages File Type
10837830 Pharmacology Biochemistry and Behavior 2012 6 Pages PDF
Abstract
► Neuropeptide S (NPS) increases the rewarding effects of cocaine and ethanol. ► NPS receptor antagonists were compared in rat models of cocaine addiction. ► RTI-118 selectively reduced cocaine-taking behavior when compared to SHA-68. ► RTI-118 decreased cocaine-seeking behavior provoked by several different stimuli.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats
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