| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10837843 | Pharmacology Biochemistry and Behavior | 2012 | 6 Pages |
Abstract
⺠CB1 antagonists are clinically effective antiobesity drugs, but induce severe anxiety. ⺠We tested if this profile can be improved by concurrent CB1 and mGluR5 antagonisms. ⺠Rimonabant and MTEP exerted synergistic effect in reducing food-intake in rats. ⺠Anxiogenic-like effect of rimonabant was abolished by MTEP in the adult rat USV test. ⺠Impaired fear-conditioning caused by MTEP was not ameliorated by rimonabant treatment.
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Authors
Balázs Varga, Ferenc Kassai, István Gyertyán,