| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10837893 | Pharmacology Biochemistry and Behavior | 2012 | 11 Pages |
Abstract
⺠Opioid tolerance and efficacy were examined using the [35S]GTPγS assay. ⺠Efficacy estimates correlated with historical analgesic efficacy estimates. ⺠Decreased μ-opioid receptor density produced tolerance in the [35S]GTPγS assay. ⺠Analgesic tolerance was observed following all treatment protocols. ⺠These data indicate that tolerance is agonist and response dependent.
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![[35S]GTPγS binding and opioid tolerance and efficacy in mouse spinal cord](/preview/png/10837893.png "First Page Preview: [35S]GTPγS binding and opioid tolerance and efficacy in mouse spinal cord")
Authors
Priyanka A. Madia, Dipesh M. Navani, Byron C. Yoburn,