Article ID Journal Published Year Pages File Type
10837906 Pharmacology Biochemistry and Behavior 2012 8 Pages PDF
Abstract
► L5 spinal nerve ligation increased CGRP-IR in laminae I-II of the spinal cord. ► SNL increased NPY-IR in the spinal cord. ► SNL induced expression of NPY-IR in dorsal root ganglion neurons only at L5. ► Subcutaneous ketanserin reversed evoked upregulation of CGRP and NPY. ► Maladaptive changes in CGRP and NPY mediated bioactivity of 5-HT/5-HT2A receptors in neuropathic pain.
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