| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10837907 | Pharmacology Biochemistry and Behavior | 2012 | 7 Pages |
Abstract
⺠We studied pain processing and morphine antinociceptive effects in MK knockout mice. ⺠Nociceptive transmission is not altered by the absence of endogenous midkine. ⺠Morphine antinociceptive effects at the spinal level are enhanced in MK-/- mice. ⺠Enhanced morphine effects in MK and PTN KO mice are not related to adrenergic changes. ⺠Differences between morphine-treated MK-/- and PTN-/- mice are discussed.
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Authors
Esther Gramage, Yasmina B. MartÃn, Gonzalo Herradon,