Article ID Journal Published Year Pages File Type
10837913 Pharmacology Biochemistry and Behavior 2012 7 Pages PDF
Abstract
► Acetaldehyde mediates some of the behavioral effects of ethanol (EtOH). ► We have chosen Aldh2−/− mice, which are deficient in the enzyme ALDH2, and ApoE−/− mice, which are deficient in ApoE. ► Using two behavioral assessments, spatial memory was measured after acute exposure to EtOH in these mice. ► We conclude that high EtOH and AcH impair spatial memory in mice. ► In addition, genetic differences might underlie some of EtOH's effects on memory.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
High ethanol and acetaldehyde impair spatial memory in mouse models: Opposite effects of aldehyde dehydrogenase 2 and apolipoprotein E on memory
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