The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function

► Three clinical analgesics were tested in rat algogen and neuropathic pain models. ► We compared the pharmacological sensitivity of evoked with non-evoked pain(s). ► Sensitivity of evoked and non-evoked pain(s) differed in neuropathic rats. ► Sensitivity of non-evoked pain(s) differed between algogen and neuropathic rats. ► Drug effects on motor function affected predictive capacity of pain models.