| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10837934 | Pharmacology Biochemistry and Behavior | 2013 | 9 Pages |
Abstract
⺠Mephedrone and methylone are new cathinone-derivative designer drugs. ⺠We investigated the neurochemical and behavioral effects of these drugs in rodents. ⺠Methylone reduced serotonin levels in rats whereas mephedrone produced no change. ⺠Mephedrone reduced working memory performance of mice in T-maze. ⺠In rodents, both biochemical and behavioral gauges of neural function are affected.
Keywords
AMPHnorepinephrine transporterMAO-B5-HTTMAO-ADATCatechol-O-methyltransferaseGFAPCOMTCCDLLOQVMAT-2TAAR1MDMA5-HT3,4-methylenedioxymethamphetamineEDTAEthylenediaminetetraacetic acidDopamine transporterstandard deviationanalysis of varianceANOVAtyrosine hydroxylaseWorking memorylower limit of quantificationNETstandard error of the meanDopamined-AmphetamineSerotoninserotonin transporterNeurotoxicitycharge coupled deviceMETHMethamphetamineMethyloneSEMMonoaminemonoamine oxidase Amonoamine oxidase Bvesicular monoamine transporter 2mephedronenorepinephrinehomovanillic acidGlial fibrillary acidic proteinHVAhigh performance liquid chromatographyHPLCCathinone
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Authors
Bjørnar den Hollander, Stanislav Rozov, Anni-Maija Linden, Mikko Uusi-Oukari, Ilkka Ojanperä, Esa R. Korpi,