Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice

Article ID	Journal	Published Year	Pages	File Type
10837937	Pharmacology Biochemistry and Behavior	2013	9 Pages	PDF

Abstract

âº Zinc effusion olfactory epithelium lesions were given to morphine addicted mice. âº The effect of ZnE on morphine sensitization and reinstatement was examined. âº The ZnE was found to impair the sensitization and reinstatement behaviors. âº c-Fos expression following reinstatement was decreased in ZnE treated mice. âº Olfactory epithelium lesions helped promote abstinence and limit relapse potential.

Keywords

c-fos ZnSO4 olfaction conditioned place preference Sensitization morphine

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice

Authors

Haichen Niu, Yingwei Zheng, Tanzeel Huma, Joshua D. Rizak, Ling Li, Guimei Wang, He Ren, Liqi Xu, Jianzhen Yang, Yuanye Ma, Hao Lei,