Article ID Journal Published Year Pages File Type
10838016 Pharmacology Biochemistry and Behavior 2012 7 Pages PDF
Abstract
► Effect of PDE4 inhibition against streptozotocin (STZ) induced neurotoxicity. ► STZ produced cognitive dysfunction and increased oxidative stress in rats. ► RO-20-1724, a PDE4 inhibitor, attenuated STZ-induced neurotoxicity. ► PDE4 inhibition may be useful strategy to treat neurodegenerative disorders.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats
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