| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838035 | Pharmacology Biochemistry and Behavior | 2012 | 6 Pages |
Abstract
⺠Asiaticoside has a potent neuroprotective effect in a rat model of parkinsonism. ⺠It improves MPTP-induced impairment of locomotor in rats. ⺠It attenuates the MPTP-induced reduction of dopamine in the striatum. ⺠It maintains redox balance and up-regulates the ratio of Bcl-2/Bax for its activity.
Keywords
MDADOPACMPTPAsiaticosideDHBATBARSqRT-PCRLPOGSHTBA1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine3, 4-dihydroxyphenylacetic acidThiobarbituric acidParkinson's diseasesubstantia nigraDopamineRedoxmalonyldialdehydeNeuroprotectionthiobarbituric acid reactive substanceshomovanillic acidquantitative real-time polymerase chain reactionLipid peroxidationHVAreduced glutathionehigh-performance liquid chromatographyHPLC
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Authors
Chang-Liang Xu, Qi-Zhi Wang, Ling-Mei Sun, Xiu-Min Li, Ji-Min Deng, Lu-Fan Li, Jin Zhang, Rong Xu, Shi-Ping Ma,