| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838042 | Pharmacology Biochemistry and Behavior | 2012 | 10 Pages |
Abstract
⺠Chronic DFMO treatment depleted putrescine in the hippocampus and prefrontal cortex. ⺠Chronic DFMO treatment decreased spermidine levels in the brain. ⺠Chronic DFMO treatment decreased agmatine level in the CA2/3. ⺠Chronic DFMO treatment impaired spatial learning and memory specifically. ⺠Endogenous polyamines are important for learning and memory.
Keywords
DifluoromethylornithineOrnithine decarboxylaseSVZi.c.v.intracerebroventricularDFMONOSODCPFCLC/MSSpermineSpermidineγ-aminobutyric acidGrowthdentate gyrusputrescineprefrontal cortexsubventricular zoneNitric oxidenitric oxide synthaseHippocampusLiquid chromatography/mass spectrometryhigh performance liquid chromatographyHPLCGABASpatial learning and memory
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Authors
Neeraj Gupta, Hu Zhang, Ping Liu,