Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10838047 | Pharmacology Biochemistry and Behavior | 2012 | 8 Pages |
Abstract
⺠Lu AA47070 is a novel adenosine A2A antagonist. ⺠Lu AA47070 suppressed pimozide-induced tremulous jaw movements in rats. ⺠Lu AA47070 also increased locomotion and decreased catalepsy in pimozide-treated rats. ⺠Lu AA47070 reversed the effects of haloperidol on effort-related choice behavior. ⺠Lu AA47070 may be useful for treating parkinsonism and depression.
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Authors
Lyndsey E. Collins, Thomas N. Sager, Anette G. Sams, Adam Pennarola, Russell G. Port, Mona Shahriari, John D. Salamone,