Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10838054 | Pharmacology Biochemistry and Behavior | 2012 | 9 Pages |
Abstract
⺠We used in vivo and in vitro models to study developmental ethanol effects. ⺠NMDAr activity during withdrawal appears to play a role in ethanol damage. ⺠CP-101,606, an NMDAR NR2B antagonist, was administered during ethanol withdrawal. ⺠CP-101,606 reduced cell death in hippocampal slices during ethanol withdrawal. ⺠CP-101,606 reduced behavioral deficits associated with neonatal ethanol exposure.
Keywords
NTCLSDPNDBECFASDNMDARHBSSOHSCITIGlutamate antagonistfetal alcohol spectrum disorderPrenatal alcoholhippocampal slicesBehavioral teratologyminimum essential mediaDIVdays in vitropostnatal dayHIHSdentate gyrusintertrial intervalorganotypic hippocampal slice cultureMEMNeuroprotectionHank's balanced salt solutionPropidium iodideN-methyl-d-aspartate receptor
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Authors
B. Lewis, K.A. Wellmann, A.M.H. Kehrberg, M.L. Carter, T. Baldwin, M. Cohen, S. Barron,