Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10838059 | Pharmacology Biochemistry and Behavior | 2012 | 6 Pages |
Abstract
⺠We examine whether MCH and MCHR1 mRNA expression, affects conditioned taste aversion (CTA) in the rat. ⺠We examine whether i.c.v. injections of MCH during the acquisition and retrieval of LiCl-induced CTA, would alleviate aversive responses. ⺠MCHR1 mRNA was up-regulated in the hypothalamus and brain stem, MCH mRNA was significantly higher in the hypothalamus, and there was a strong trend suggesting an elevation of MCH and MCHR1 genes in the amygdala. ⺠Central administration of MCH did not reduce the magnitude of Li-Cl dependant CTA.
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Authors
Anaya Mitra, Anica Klockars, Blake A. Gosnell, Madeleine Le Grevès, Pawel K. Olszewski, Allen S. Levine, Helgi B. Schiöth,